I started the Clomid this month on days 5 - 9 (I'm currently on day 14 of my cycle). I'm taking just 50mg to start with to see what happens. I wasn't quite sure what to expect since I've heard some horror stories about how people felt on the Clomid.

These are the symptoms that I had:

On the first two days (so days 5 6) I was very emotional and teary. Much worse than regular PMS. I was crying at ads on TV over random comments people made. But I figured it must be due to the Clomid so I didn't pay attention. The last three days of taking it I didn't have any symptoms at all, so I guess my body got used to it pretty quick.

I have noticed that my cervical mucus is all over the shop. According to the OPK's I haven't ovulated yet, but I've had lots of ewcm.

I was surprised at that because I had heard that your cm dries up on Clomid, but I seem to have more than normal. Odd. (but good).

My partner is due to do his sperm test next week. He originally scheduled it for today but I told him he had to change it because I'll probably be ovulating soon (fingers crossed). We've been having sex every few days anyway just in case the OPK's never go positive.

I haven't been charting for a few months because I found it just too stressful and I tend to obsess over every little temperature rise or dip. I'd rather just wait and see at the end of the two week wait rather than obsess each day.

Anyway that's where I am this month, hope you are all having great baby luck.

Tracey

P.S. I was just watching The View and Elizabeth Hasselbeck was talking about how as soon as she changed to a Gluten Free diet she fell pregnant. Interesting. I might have to get a copy of her new book and check it out.

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The Top Ten Testosterone Myths
The dark side dispelled
by TC Luoma
Testosterone is hot. It gets lead story status in big-name international newsmagazines like Time, and its been making the rounds on both national and local news programs. Everybody, it seems, is suddenly intrigued by it. And moreover, everybody seems to want it.
Its quite a hormonal role reversal, considering that only a year ago, wearing a Testosterone T-shirt would grant you automatic pariah status on any street you happened to walk down. Likewise, asking the average physician about it would get you a raised eyebrow and a lecture – delivered in the requisite condescending tone – about the evils of steroids.
Were happy that the lay public Testosterone and the concept of Testosterone replacement. It gives us delicious status.
The trouble is, for every favorable report you hear about our favorite hormone, the news organization delivering it feels compelled to offer the dark side, or the bad news about Testosterone.

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By Eric M. Potratz (Primordial Performance)
Click Here to Visit Primordial Performance
Eric M. Potratz has developed his education in the field of endocrinology and performance enhancement through years of research, counseling, and real world experience. Over the past five years he has been a private consultant for hundreds of athletes and bodybuilders alike, and is the founder president of Primordial Performance.
Preface - Over the past 15 years, the use of Clomid and Nolvadex, as Selective Estrogen Receptor Modulators (SERMs) has become a staple in the HRT and bodybuilding communities.
The popularity of these drugs stems from the popular advice to use these drugs for everything from testosterone recovery, bloat reduction, to gyno prevention. In many communities SERMs have become akin to vitamins vitamins that can do no wrong and provide seemingly endless benefits.
This article is not intended to examine the proper use or possible applications of Clomid or Nolvadex. Instead, we will be exploring the historical development of these drugs, the short-term side-effects and long-term consequences.
As I will illustrate, these drugs are true danger to men’s health.
Synthetic estrogens, the beginning -
It was the 1930’s and there was a new age of hormone-dependant pathologies on the rise. Scientists were eager to determine the structural requirements of estrogen for new drug design.
In 1937 Sir Charles Dodd of the Middlesex Hospital of London found estrogenic activity in a molecule with two benzene rings linked together via a short carbon chain (eg, diphenylethane). (1) Soon thereafter, a synthetic, non-steroidal estrogen known as diethylstilboestrol (DES) was created from this basic molecular backbone. (1) By 1941, DES was an FDA approved drug, and by the 1950’s, DES gained widespread popularity as the drug of choice for menopausal symptoms, cancer treatment, and prevention of miscarriages. (2)
DES sparked the interest of ambitious drug manufactures that saw this synthetic molecule as a potential “molecular backbone” which could be tailored for estrogenic activity, and patented for maximum profit.
Within months, a research group from the University of Edinburgh found that the addition of a benzene ring to the original diphenylethane structure created an somewhat of an anti-estrogen known as triphenylethylene. (1) Although it had very weak estrogenic activity, it was called an anti-estrogen because it competed with the body’s more powerful estradiol for the ER receptors.
Although the complex estrogenic action of triphenylethylene was not fully understood, it was considered the perfect molecular platform for future drug development because of its high oral bioavailability and extended half-life due to its lipophilicity (fat solubility). As it was later discovered, the estrogenic action could be manipulated with structural modifications for more specific agonist/antagonist actions. (3) Despite the lack of understanding for its full physiological effects, triphenylethylene would become the molecular backbone for generations of SERM’s to come.
By the early 1940’s, the world’s largest chemical manufacturers, including Imperial Chemical Industries (ICI), got word of the triphenylethylene development, and seized the opportunity to expand this new class of compounds. By the 1950’s, the synthesis of new triphenylethylene based molecules had began picking up momentum, as the first FDA approved SERM’s started appearing on the market.
One of the first was Triparanol, which was sold as a cholesterol lowering SERM, until it was eventually pulled from the market in the 1950’s for causing cataracts in patients. (7) Later, Ethamoxytriphetol (MER-25) was discovered and found to be a reliable contraceptive and anti-cancer agent in rats, but failed in humans due to the drug’s severe toxicity and stimulation of “acute psychotic episodes”. (6)
Despite these early warning signs, development continued.
Among one of the newer SERM’s to appear in the late 1950’s, was a mixture of two stereoisomers zuclomiphene and enclomiphene both having unique estrogenic and anti-estrogen actions. This mixture was collectively called clomiphene, and later marketed as Clomid.
Then, in 1962, ICI synthesized ICI-46474, another mixture of a trans and cis isomers with mixed estrogenic and anti-estrogenic activity. (7) Ultimately, the trans isomer was found to be the predominate anti-estrogen, which was isolated and eventually named tamoxifen, and later marketed as Nolvadex.
Originally, ICI pushed these new SERM’s to market as a “morning after” contraceptives, which were eventually approved by the FDA. (4) Yet again, the profit hungry and presumptuous drug manufacturer based its findings on rat studies, which would prove to be a mistake upon subsequent human research that showed the SERM’s induced, rather than inhibited ovulation. (4) Needless to say, tamoxifien was withdrawn as a contraceptive.
And remember DES, the original synthetic estrogen developed back in the 1930’s? As it turned out, DES was found to increase the risk of breast cancer by 50%. Further research linked DES to millions of vaginal and testicular cancers among the children of mothers who took DES during pregnancy. (2,5)
The light on synthetic anti-estrogens was dim, and by the late 1960’s, there was little enthusiasm to continue RD with triphenylethylene based SERM’s, especially considering their inherently toxic effects (7, 10)
It wasn’t until 1971, that tamoxifen would be dug up from the dead and considered as a candidate for cancer treatment.
Treating cancer with a carcinogen –
When research is done on anti-cancer drugs (such as SERMs), the aim is to find a drug that prolongs life, with the least amount of acute side-effects. In other words, the goal isn’t so much about finding a cure, as it is finding something that can alleviate the symptoms and/or prolong life.
For an estrogen dependant cancer, the idea was simple – Block the proliferative action of estrogen with an anti-estrogen and slow the cancer growth. What could be more appropriate than an already available, orally active, patentable synthetic estrogen such as tamoxifen? It was a practical shoo-in.
Therefore, in 1971, when drug researchers decided to examine all of the historical anti-cancer SERM data, they found that all of the SERM’s showed anti-proliferative activity on estrogen dependant cancer, and all of them demonstrated some extent of toxicity. (10, 37-39) However, the SERM that happened to show the least amount of toxicity was tamoxifen. (clomiphene missed the mark by showing a high rate of cataract formation)
At the time, Pierre Blais, a well known drug researcher, commented on the finding (5) -
“Tamoxifen is a garbage drug that made it to the top of the scrap heap. It is a DES in the making.
In spite of the criticism from a number of researchers, the FDA approved tamoxifen as a cancer treatment in 1977, and in 1985 ICI was awarded a US patent for tamoxifen in the treatment of breast cancer. (5) Soon, tamoxifen would become the most popularity prescribed cancer drug.
“Its FDA approved for cancer treatment. It must be safe!”
It’s wrong to assume that an “FDA approved” drug has a proven safety profile. The FDA has continually issued stronger health warnings for tamoxifen over the years. For instance, in 1994 the FDA demanded that the tamoxifen manufacturer Zeneca (an ICI sub-division), issue warning letters to health care practitioners about the increased risk of endometrial and gastro-intestinal cancers with tamoxifen use. Zeneca also reported adverse effects similar to those seen with DES, such as reproductive abnormalities in the animals whose mothers received tamoxifen. (remember, DES was the original synthetic estrogen, and also an analog to tamoxifen)
A number of cancer researchers have pointed out the health risks too, such as Elwood et al (6) -
“[Tamoxifen], therefore, is not appropriate for use in the general population because of the known increased risk of endometrial cancer”
“So why is tamoxifen the most popularly prescribed cancer drug, if it’s so toxic?”
The answer is simple. Tamoxifen is the lesser of two evils.
Tamoxifen remains the most popularly prescribed drug because it is one of the few drugs that has shown a “statistically significant” improvement of the survival rate of breast cancer patients.* (Not to mention, tremendous financial motives and intraworking’s from its patent holder Zeneca)
Remember, the goal in cancer treatment is to prolong life even if it means committing to therapy that is potentially cancerous or injurious to future health (as confirmed in long-term follow up’s and close examinations of tamoxifen patients).
So, perhaps the risks are worthy for the cancer patient, but are they worthy for the health conscious male?
* Most research has shown tamoxifen to improve the survival rate by 4-14%. For instance, over a 5 year period, 74% of the women survived who used tamoxifen, compared to 70% of the women on placebo. Depending on the type of cancer, this may translate into an extra 2-3 years of life for a cancer patient. (9) Continuing tamoxifen therapy for more than 5 years, results in increased tumor recurrences and serious side effects. (8)
Translating the science, for men’s health -
Fast forward 30 years, through hundreds of human and animal trials and we find that the research is quite extensive, and contradicting. (21)
The damaging evidence from many early rat studies showed severely toxic effects, including the development of cancer in the liver, uterus, or testes upon tamoxifen administration. (30-34,41) However, this evidence was largely disregarded by further test tube studies on human cell-lines which appeared to show a lack of toxic effects. (21)
This misleading test tube data gave the green flag to perform large scale human studies with tamoxifen in the 80’s and 90’s. Even more misleading, was the majority of the human research described tamoxifen as having a “low incidence of troublesome side effects” and that the “side effects where usually trivial”. (22)
As science would uncover, the lack of human toxicity reported in original tamoxifen research was a result of insufficient study duration, inability to detect low level DNA damage with insensitive methodologies, and/or misdiagnosis of collateral cancers as metastasis infections from the breast cancer itself. (15, 21, 28-34)
A word on clomiphene (Clomid) –
Clomiphene (Clomid) consists of two stereoisomers which possess radically different pharmacodynamics. Zuclomiphene has predominantly estrogenic effects and slow clearance while the enclomiphene isomer has predominately anti-estrogenic effects and quick clearance. (9) This creates a dichotomy between estrogen blockage and estrogen stimulation and an acute imbalance once Clomid administration is discontinued. Bodybuilders will often complain of “estrogenic rebound” after stopping Clomid, which could be attributed to the lingering estrogenic isomer zuclomiphene as the anti-estrogenic enclomiphene has long cleared the system. (Recently, enclomiphene has been isolated by the pharmaceutical company Repros, for use in Androxal™.)
For all intents and purposes, tamoxifen is a superior SERM, simply for the fact that tamoxifen provides a purely anti-estrogenic isomer, whereas Clomid provides a mix of anti and pro estrogenic effects.
In regards to the health consequences about to be listed, it can be safely assumed that Clomid will share similar detrimental effects as tamoxifen, since it shares the same triphenylethylene backbone and carcinogenic tendencies. (44,45,57,58)
Liver cancer -
Originally, tamoxifen was accepted as being non-toxic to human liver upon finding that tamoxifen did not cause noticeable liver damage (DNA adducts) during short-term test tube studies with human liver cells. (35,36)
However, it became apparent that test tuberesearch was largely flawed due to the low rate of metabolism in such a superficial environment. (21) It was soon discovered that the hepatotoxic effects from tamoxifen are from the metabolism and buildup of the a-hydroxytamoxifen and N-desmethyltamoxifen metabolites, which would only appear in an in vivo environment. (15) Surely enough, the results from the original rat studies showing dramatic carcinogenic effects on the liver, 30-34,41 soon correlated with human data when researchers found the same type of liver DNA adducts in tamoxifen patients. (15, 28-34)
More recent human research has reported tamoxifen treated women to have 3x the risk of developing fatty liver disease, which occurs as soon as 3 months into therapy at only 20mg/day. (24-26) In some cases, the disease lasts up to 3 years, despite cessation from tamoxifen therapy. Five and ten year follow-ups with patients on long term tamoxifen therapy shows cases of deadly hepatocellular carcinoma. (27-29)
In 2002, a bizarre study examined the use of tamoxifen for hepatocellular carcinoma treatment in humans. It was assumed that since tamoxifen could inhibit proliferation of breast cancer, it could offer the same benefit for liver cancer. The devastating results could not have been further indicative of tamoxifen’s hepatotoxic nature, as the tamoxifen treatment significantly increased the rate of death, compared to the group not receiving tamoxifen. (14)
Finally, in a case study reviewing tamoxifen induced liver disease; D.F Moffat et al made a profound statement –
“hepatocellular carcinoma in tamoxifen treated patients may be under-reported since there may be reluctance to biopsy liver tumours which are assumed to be secondary carcinoma of the breast.”
In other words, it appears that the liver carcinoma from a large number of breast cancer patients on tamoxifen therapy has been misdiagnosed as an infection from the breast cancer itself. (28)
Although tamoxifen induced liver cancer may take years to manifest in a healthy male, its damaging effects could easily be exaggerated by other popular hepatotoxic drugs, such as 17aa oral steroids. (15)
Prostate cancer -
In 1996, the International Agency for Research on Cancer (IARC) concluded that tamoxifen clearly promotes uterine cancer in humans – at a standard 20mg/day dose. (16,23,42) This is due to tamoxifen acting as an estrogen agonist in the uterus, presumably from the 4-hydroxytamoxifen metabolite, which triggers abnormal growth of the uterus and the formation of cancer causing DNA adducts. (33, 40)
Contrary to popular thought, these implications are quite scary for a male when we realize the male equivalent to the uterus is the prostate – which differentiates from the same embryonic cell line, shares the same oncogene, Bcl-2, and high concentration of estrogen receptors. In fact, there is no reason to assume that tamoxifen would not initiate the same cancerous growth in the prostate. (60-62) It is no wonder that tamoxifen failed as a treatment for prostate carcinoma. (43)
Note: This same risk would be applicable to Clomid, which has also been linked to uterine cancer and ovarian hyper-stimulation. (18, 19, 57, 59)
Libido reduction erectile dysfunction -
Erectile dysfunction, low libido, and general impotence are typical complaints from men recently discontinuing steroids or HRT therapy, which is often combated by Clomid or Nolvadex, paradoxically so.
Regardless of any positive effects on fertility or testosterone levels, Clomid and Nolvadex use is highly correlated with erectile dysfunction, libido suppression, and even emotional disorders. (10,47)
Research with male breast cancer patients has also reported decreased libido, and thrombosis associated with tamoxifen use. (47) The thrombotic effect (blood vessel clogging) could explain the mechanism by which SERM’s may inhibit erectile function, by reducing circulation to erectile tissue. (47, 52)
Increased susceptibility to gyno -
Tamoxifen is often used to combat gyno during cycle when “flare ups” occur. While tamoxifen may provide immediate inhibition of proliferation, and serve as valuable tool, it can actually increase future susceptibility to gyno.
This is caused by tamoxifen’s ability to up-regulate the progesterone receptor. (54-56) This can dramatically increase the chances of developming gyno in future cycles when utilizing progestin based anabolics such as Nandrolone (Deca) or Trenbolone (or any pro-hormone acting upon the progesterone receptor).
It is interesting to speculate. Is tamoxifen use directly related to the increased gyno occurrences seen with modern day steroid users?
Ocular toxicity –
Another possible side effect associated with SERMs is visual cloudiness, loss of vision and even cataract formation. Although this tends to be a more common side effect from high dosed SERM therapy, standard 20mg/day tamoxifen regimes have been reported to cause these symptoms of ocular toxicity. (17, 46)
Newer SERM’s -
As the medical community became more aware of the side-effects associated with tamoxifen treatment, newer and safer SERMs, such as toremifene and raloxifene hit the developmental fast track. Toremifene appears to be less liver toxic, but it is a closely related analog of tamoxifen, so it also carries many of the related genotoxic effects. (48,49)
Raloxifene is a newer SERM based off a benzothiophene structure, which appears to make it less toxic in the liver, uterus or prostate. (50-52) Unfortunately, Raloxifene has been associated with a higher incidence of thromboembolism (52), and also has very low oral absorption, making it an expensive alternative at a typical dose (120mg/day). (53) Still, Raloxifene could presumably be equally effective as Clomid or Nolvadex at restoring HPTA function, while imparting less side effects. (53)
Newer SERMs are already being evaluated such as bazedoxifene, arzoxifene, and lasofoxifene, in hopes of reducing risk even further. (further enumerating the evidence of toxicity with the tamoxifen generation of SERM’s)
What to do now?
Firstly, it should become a priority to create awareness about the possible side effects of SERMs. Once educated, users will be able to start reducing their requirements of these drugs, and begin adopting healthier, more responsible alternatives.
Carefully planned cycles, and the proper use of aromatase inhibitors (AIs) must pursue over haphazard combinations of excessively dosed aromatizing AAS’s which require high doses of SERM’s to reduce possible side-effects. Whereas avoiding SERM’s in HRT will involve the natural clearance and management of endogenous estrogens.
It will be important to maintain testicular function during cycle for a quick and efficient recovery of natural testosterone production for PCT – negating the need for high dose 2-3 month SERM based PCT’s. (For more information on the proper use of hCG during cycle, visit here)
Thus, abolishing the bad habit of SERMing will involve community wide enlightenment with careful, comprehensive planning of worthy alternatives.

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“On occasion, elite bodybuilders stay on steroids for several years at a time. This is due to the fact that they must be in shape for multiple contests as well as guest appearances throughout the year. This non-stop regimen has claimed some victims. Mendenhall comes to mind. This guy had the potential to be one of the best bodybuilders in history. Yet, he admittedly burned out on steroids before he could even claim a national championship. Hill is another bodybuilder which I have recently seen suffer from the demanding, non-stop steroid regimen required at this level. After rocketing to the top, he has recently dropped out of sight. Demelo was another up and coming national competitor who burned out on steroids and never made it. I think he is trying to make a “natural” comeback - - good luck, bud. Santoriello took a serious setback after his teenage success before coming back to win the national championships. I heard that he was messed up by steroids. Some don’t think he can make it as a professional because of the amount of drugs he has to take to stay in shape. (Oh, I mean the amount of Cybergenic Kits - give me a break!). Numerous pro bodybuilders and active top level national competitors find themselves in similar situations. Their contest schedule is just too busy for off cycle periods. Since their success is so heavily dependent on being in top shape, steroids become an absolute must for their program all year long”.

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So my "new" cycle that has been happening since yesterday has been the most unusual I have ever had yet. Pain and no heavy or even medium flow, very light watery and red. Then today for awhile it was more heavy and now tapering off again. A lot of blood clots and some brown and red color. I am so confused because I have no pain at all any more, almost could say no cramps at all either. Today is CD2 of my new month because I am assuming that this is a new cycle and this is AF that is happening. I have never felt pain like that before and it was there and gone so quickly. I was so tired yesterday too. DH said I looked exhausted, my body was just wore out completely and I did not want to move once we were home. Today was a little easier for me. When I was tired today I just took a little nap for awhile, seemed to help. I still have no idea if what I experienced was a miscarriage. When I call the doctor's office on Monday they will probably tell me that there is no way to tell this early, that it is a new cycle, to begin taking my Clomid on CD5 and set up my blood test for my CD23 to test my Progesterone level. However I believe that it is a good idea for DH and I to come in to the doctors office and talk over a few things. I want to understand why we are not conceiving yet and see what we can do. May have to do another SA and perhaps look and see if my cysts have come back and could be what is preventing us from having a baby. I just hope that this next month, no matter what, is our month. It is so difficult and I almost felt like giving up all together after this time, but my desire to keep going till I see a BFP is stronger than giving up. I just hope that this next time that AF is due that she doesn't show up, not till after nine months and after our HH baby is born.

Went back to the Greater St. Louis Book Fair at West County Mall this morning. Arrived right at the start of the 9am - 10am hour for people with disabilities. Really helped me out last year getting around without bumping into all of the people. There was so much less there today and so much I should have picked up yesterday. Every year there seems to be less and less because so many more people find out about the book fair every year. DH and I have been going for years now and look forward to it every year. I finally have myself a copy of 'Lucky Man', and several fertility and infertility books, one book about a woman's journey to having her family, a book by Anne Rice, and a vegetable cook book. DH got several books as well. Overall good amount of books we were able to get for the variety of books that were there.

Took advantage of K-Mart's sale that they had going this week. The double or triple your coupons. We saved 25 dollars and spend 24 dollars. It is like getting over half of your groceries for free, which is always great!

DH did not feel well again today which worries me. Same dizziness and light headedness as before. Was there before the book fair and then slowly got worse. Then went to my MIL's house and we all visited and had a late breakfast together. Then we all went to K-Mart together, in separate cars so we could drive home afterward, and DH felt ill again so we left. Feeling finally went away later once we were home but then when we had to drive out to Walmart to pick up two things the feeling came back again. Now we are home and DH is beginning to feel a little better. It is the not knowing that is more frightening and I am worried that what he is experiencing is stress, anxiety related or have something to do with his heart or some type of disorder where the brain makes you freak out in certain types of environments. Hopefully DH will get ahold of his doctor this week and be able to schedule the Tilt Table test. Have to rule out that it is not his heart before we can move forward and look at the stress, anxiety, or anything else it may be. Worried like crazy about my DH because I just love him so much and want him to be ok. Trying to remain hopeful and not worry so much. But that is like asking a person to hold their breath forever and not breathe. As long as we don't know what is happening, I will be worried.

Finally turned on the air conditioner today. Feels nice. It is on 75 or 77, can't remember exactly what, and feels much better than the 85 degrees that it was earlier today. Yesterday we had all the windows open and fans going. Was not terrible but much nicer now with the air on.

Not much else to write for tonight. I have been staying away from parents.com and mostly just writing updates here on the blog when I have a thought over these past two days. I have gone through so much emotion and have spent very little time on the internet. Tonight has been the first time that I have taken an hour to check all of my email, go on facebook and myself and write updates. I am been keeping myself away from the world and am now ready to face it again. With a more positive outlook on this situation, still clueless as to what exactly happened, but hopeful that this next month will be better and that I will get a BFP very soon.

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I had my annual gyn appt yesterday - it was two hours (most of it waiting) but it went pretty well. The Dr. was not impressed with my ovusoft charts, though. He said bbt's are too unreliable - I just said that I had to disagree and left it at that. He was supportive of my use of NPC but was skeptical that it would help me to ovulate on my own. I am just going to keep fingers crossed and think positively!
Today my cervix is again soft, high and open and I had a big temp dip down to 96.44 today! Praying that I actually O on my own so I can supplement with the NPC soon.
I am continuing to increase my daily fruit/veggie intake and lower my refined sugars/carbs. I am eating only healthy carbs such as whole wheat pasta, brown rice, etc... and only one serving per day. I am losing my tummy, which is great! I'm really trying to be healthy and I hope that the NPC will be a good supplement in the lp for me.

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Our community is dedicated to offering a friendly environment in which to chat about all things family related. Whether you are planning for your first or expecting another baby, you will always find like minded members to talk and make friends with. Look though our numerous subject specific forums or feel free post about anything you want to chat about. Join the community by Registering and don't forget to Introduce Yourself so we can all get to know you.

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What a shit fortnight.

DD (4) develops a nut allergy so frightens the life out of us. Doctor gives little information and we suddenly can't buy or eat any of the things we did before.

A small building project I've been trying to get off the ground for years, suddenly has to be started like yesterday and I have to research and source supplies quick - a thing I've never done before but can't afford to get it wrong as thousands of pounds are at stake.

My first cycle of clomid dictates that I make 3 x 2 hour round trips in the same week to the nearest hospital for my scans. I could do without the travelling, the expense and the stress of it. Apparently, I released one egg on the clomid but the consultant wants me to produce 2 so they want me to up my dose to 150mg. This freaks me out. I had bad migraines every other day for 10 days with 100mg. How much am I prepared to put myself through?

I have to educate both DD's nursery and her new school she starts after Easter about the allergy. Also wash, iron, pack our bags and get the house straight for our trip to Scotland to see DD's grandma. Run round like headless chicken feeling overwhelmed and underpaid.

We get as far as Gretna and have to turn back as DD comes out in chickenpox.

3 days and nights of hell. She's in a lot of pain with the spots especially one on the sole of her foot so she can't walk. She's screaming when we try and move or bathe or put cream on her or anything in fact. She screams so long and so loud one day that my head explodes and I scream back at her. We all have no sleep.

DD's new bed with a ladder arrives today. DH is on hols from work and is keen to put it up straight away. We have a whole conversation about how as DD's foot is sore she may not be able to manage the ladder so for tonight we'll put her old cotbed underneath the new high sleeper one, like a bottom bunk bed so she can get in and out of it easily, especially several times in the night when she's feeling so wretched. At least I THOUGHT we'd had that whole conversation. Apparently, I'd just been talking out loud to myself. DH has dismantled DDs old bed so she'll have to struggle up and down a bloody ladder on one foot And guess who's going to have to cope with the fallout? I shout at him over lunch and him and DD have gone upstairs together. No doubt to get away from me.

I want to blame the clomid for me being a complete bitch. I want to blame it on some hormonal imbalance anyway so that I don't have to take responsibility for my behaviour. I want to imagine it's pregnancy hormones. After all, I did release an egg from the ovary that has a tube attached and DH and I were speaking enough at that point to have sex so, you see, it is possible that I might be pregnant! The fact that I've been wrong 28 out of the 30 months we've been trying is not good odds though. I've likely been a bitch because my period is about to start.

Ooh, I should say that something nice DID happen to me this fortnight, a lady stuck some pins in me and burnt me with a fat jostick last thursday. Thank goodness for the acupuncturist. She has to put up with my ranting because she's paid to.

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CD 8

I had a very strange phone call from one of the receptionists at my doctors surgery and she introduced herself and then said to me 'Are you pregnant?' I replied no and she said 'Are you sure?' I said 'well I don't think I am as I had a period last week' She then asked if I'd done a test which I had a day or two before I was due on and that was negative!

I asked why as she kept asking if there was any way I could be pregnant and she said it was just because my iron levels were so low. I'm wondering now though if there is more to it than that though. Yesterday I went for a Haematinic Screen Blood Test and was told to expect the results in a week or so but then I got this phone call.

The doctor has given me a prescription for more iron tablets today (picked them up and there were 100 of them - I still got about 60 left from the hospital too) and have another blood test done in 2 weeks to check my iron levels again. Hopefully they should have improved by then as I am terrible at taking tablets. I really struggle to swallow them and end up flapping my hands about in front of my face to help them go down. Thankfully they are only small tablets so its not too bad. I remember I had some huge ones once and the only way I could swallow them was on a spoon mixed in with jam and even that wasn't always successful lol!!

I will be very glad when I can stop the iron tablets though as I hate the side effects. Not nice!! I've been very good at taking them and also my clomid. Usually when I get prescribed tablets I am always forgetting to take them but have done ok with both of these so far!! I am starting to feel a little better in myself and not quite so tired and feel I have a little more energy and have been able to stay awake til 11pm at night which is much more productive for babymaking!! Also not been getting up til 8.30am so thats much improved on the 7am I seemed to be waking up before the clocks went forward (or backwards was it? - I always get them mixed up!!) Long may it continue.

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We order nearly everything today over the Internet. Food, books, music - nearly everything that can be bought is purchased over the Internet.
Many people who dismiss the idea of buying this way cite the fear of having their personal and financial info stolen. There are many ways that this information can be stolen, including dumpster diving, phishing, and other means. So the reluctance that many people have to order online is no more or less significant than their arguments to use credit or debit accounts in a store, over the phone, or anywhere else. Things have changed in this world, and the change isnt going to stop.
Among the limitless products available over the Internet are pharmaceuticals, including Cialis and other erectile dysfunction drugs. Driving to the drugstore to pick up a prescription is becoming a thing of the past. The online pharmacy has replaced the corner drugstore for many people for a number of reasons, including the relative safety and ease of online ordering. A legitimate, reputable online pharmacy will employ a number of security measures to make sure your valuable information wont be stolen. And as the consumer, you have every right to find out about these security measures before you make an online prescription purchase.

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After my discharge from the hospital, it took me about a week and a half to recover from the laparoscopy. I needed assistance rising from a lying or seated position, on and off the toilet, bathing. I have three small scars, one in the navel, and the other two where my ovaries are/were. When I began employment in April 2004 as a corporate security officer, my health was still iffy. I was still too thin at 109 pounds. I was gaunt, frail, even the slightest common cold would set me back two weeks. To top it off, I was commuting from an hour or more North, twice a day, five days a week. One early morning as I returned home from a double shift, I fell asleep at the wheel and ended up with $3,500 worth of damage to the front end of the car I had just bought. In 2006, I moved closer to work finally. In November of that year, I had a bad experience at work one night as I was performing a routine foot patrol in my building. I suddenly felt extremely nauseous, shaky, and dizzy. I had stabbing pain that was so bad I could barely walk, and I actually had to lie on the floor. I considered radioing my supervisor for assistance, but my pride stood in my way. I had another pain episode that December.
My mother told me about an article that she had read in Womens Day magazine about a clinic in Florida called Clear Passage. It consisted of deep tissue massage for women with infertility and pain caused by infertility. They also claimed to open blocked fallopian tubes. Because I really wanted to have a child, I decided to give Clear Passage a try.
After securing credit and a payment plan, I flew to Florida in June 2007 and spent a week in wonderful weather. For two hours at a time, twice a day, five days a week, I endured some pretty painful external and internal manipulation. I was always tired, yet felt good, when I left the clinic for my hotel room. I went to Walt Disney Worlds Magic Kingdom and Sea World for the first time, and I cried at both places because I was so thrilled to be there. Those were the trips I dreamt of as a little girl, and there I was at age 33. I felt that the therapy helped me in most of the areas except my TMJ (temperomandibular joint) pain, which I feel has been made worse. The therapy is touted to last for two years, and as I approach the two year mark this coming June, I see signs that my old uncomfortable feelings during each menses is beginning to creep back in.
I am returning back to searing lower right back pain and ovarian pain, which requires Vicodin as needed and a couch or bed with my heating pad and some rest. At this point, I plan to let things slide and continue to do as I am doing to manage my pain. I also decided to eliminate most of the main offending items from my life as possible, mainly certain food and body products. Endometriosis feeds off of estrogen, a womans primary hormone. After doing some research, I decided to consume organic offenders: meats, dairy, and eggs. I now consume organic or all-natural beef, chicken, pork, milk, cheese, and eggs. Body products containing chemicals called parabens (methylparaben, ethylparaben, propylparaben, etc.), pthalates, and chemicals ending in the suffix -eth (laureth, etc.) are offenders in products such as hair care, body lotions, and cosmetics. I am a huge fan of Burts Bees lotions. They smell great, a little goes a long way, and they work well without a tremendously greasy after feel. I finally put on weight, going from 109 in 2004 to 135 today.
Because Clear Passage did not succeed in opening my remaining right fallopian tube, my hospital has determined that IVF (in vitro fertilization) is likely my best bet in becoming a mother.

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Parlodel ( Bromocriptine ) 2,5 mg is a stimulator of dopamine receptors. Inhibitor of secretions of prolactin.
Indications
Infringements of a menstrual cycle, female barreness.
Parlodel-dependent diseases and the conditions which are accompanied or not accompanied by hyperparlodelemia:
– amenorrhea (accompanied and not accompanied by galactorrhea), oligomenorrhea;
– insufficiency of a lutein phase;
– hyperprolactinemic infringements caused by medical products (for example, some psychotropic or antihypertensive preparations).
Parlodel-dependent female barreness:
– a syndrome of polycystic ovaries;
– anovulatory cycles (in addition to antiestrogen, for example clomiphene).
A premenstrual syndrome:
– morbidity of mammary glands, the hypostases connected with a phase of the cycle, meteorism, infringements of mood.
Hyperprolactinemia at men:
– parlodel-dependent hypogonadism (oligospermia, loss of libido, impotency).
Prolactinomas:
– Conservative treatment of parlodel-secreting micro and macroadenoma of a hypophysis;
– Preoperative preparation for reduction of volume of a tumor and simplification of its removal;
– Postoperative treatment if the level of prolactin remains raised.
Acromegaly:
– As additional means in a complex with radiotherapy and operative treatment or, in special cases, as alternative to surgical or radiotherapy.
Suppression of a lactation:
– Prevention or the termination of a postnatal lactation under medical indications;
– Prevention of a lactation after abortion;
– Postnatal hardening of mammary glands;
– Beginning of puerperal mastitis.
Good-quality diseases of mammary glands:
– mastalgia (in the isolated kind, or in a combination with a premenstrual syndrome or good-quality central or cystic changes);
– Good-quality central and-or cystic changes, especially fibrocystic mastopathy.
Parkinson’s disease:
– All stages of an idiopathic Parkinson’s disease and postencephalitic parkinsonism either in the form of monotherapy, or in a combination with others antiparkinson means.
Collateral action
During first several days of treatment at some patients can be marked a nausea; less often - the dizziness, the general weakness, vomiting, however these phenomena, as a rule, do not demand the termination of treatment.
Parlodel can cause a hypotension, including the orthostatic hypotension, which sometimes can lead to a collapse; therefore especially in the first days of treatment it is recommended to supervise the ABP.
Besides there are messages on development of blocking in a nose, a lock, drowsiness, headaches and, less often, confusion of consciousness, psychomotor excitation, hallucinations, dyskinesia, dryness in a mouth, spasmes in gastrocnemius muscles, allergic skin reactions and loss of hair. Usually these by-effects are doze-dependent and can be supervised at decrease in doze of Parlodel.
Sometimes at long treatment of cases of temporary whitening of tips of fingers of hands and feet in reply to influence of cold are marked, especially at patients at whom the Reyno’s syndrome earlier was observed.
Application of Parlodel for suppression of a physiological lactation in the postnatal period was accompanied by development of an arterial hypertensia in rare cases, a heart attack of a myocardium, spasmes, a cerebral insult or mental infringements.
Contra-indications
– An uncontrollable arterial hypertensia;
– An arterial hypertensia at pregnancy (including eclampsy, preeclampsia or the arterial hypertensia caused by pregnancy);
– An arterial hypertensia in the early and late postnatal period;
– CHD and other serious cardiovascular diseases;
– Serious mental diseases current and/or in the anamnesis;
– The raised sensitivity to the components of Parlodel or other ergot alkaloids.
SPECIAL INSTRUCTIONS:
care in case of application of Parlodel during the early and late postnatal period is necessary, as sometimes (about 1 case from 100 000) at application of Parlodel for prevention of a lactation revealed a heart attack of a myocardium, spasmes, an insult or mental infringements; sometimes spasmes or infringement of brain blood circulation preceded by a strong headache or time infringements of sight. At prescription of Parlodel during the early postnatal period it is necessary to supervise carefully the ABP, especially in the first days of treatment. Extra care is necessary at treatment by Parlodel of patients, recently accepted or accepting the preparations adjusting the ABP. At occurrence of a constant headache or any attributes of neurotoxicity the treatment should be immediately stopped.
It is necessary to appoint Parlodel to patients in minimal therappeutically effective dozes (except for the pathology caused by raised secretion of parlodel) for prevention of decrease of concentration of parlodel in plasma of blood below normal values, capable to be reflected badly in function of a yellow body.
At mastalgia and nodal and/or cystose changes of mammary glands it is necessary to exclude presence of malignant new growths before application of Parlodel.
At acromegalia before application of Parlodel it is necessary to exclude presence of ulcer diseases of a digestive path, and at their presence it is better to refuse from application of Parlodel or to recommend the patient to address immediately to the doctor at occurrence of any infringements from system of digestion. Care is necessary in connection with some messages on gastroenteric bleedings at patients with acromegalia on a background of treatment with Parlodel, notwithstanding that their causal interrelation is not established.
Care at purpose of Parlodel is necessary for patients with mental or heavy cardiovascular diseases in the anamnesis.
At treatment with Parlodel, especially in the first days, occurrence of a hypotension is possible, care therefore is necessary to be taken at work with various machines and mechanisms.
The bearableness of Parlodel may worsen at reception of alcohol.
There are separate messages on occurrence of pleural effusion at patients with parkinsonism, having received high dozes of Parlodel for a long time, therefore a patient with a pleuropulmonary pathology of not clear genesis should be surveyed carefully and a preparation should be cancelled at acknowledgement of a causal relationship.
Some cases of development of retroperitoneal fibrosis at the patients, who have been receiving Parlodel during some years in daily dozes over 30 mg are described. For duly diagnostics retroperitoneal fibrosis on early, reverse stages of illness it is recommended to pay attention to its displays (a pain in a waist, hypostases of the bottom finitenesses, infringement of function of kidneys, etc.) at the given category of patients. At suspicion or acknowledgement of presence of fibrous changes in retroperitoneal space, the treatment by Parlodel should be cancelled.
The treatment by Parlodel can restore fertility, therefore at undesirability of approach of pregnancy it is recommended to use reliable methods of contraception. At approach of pregnancy it is recommended to cancel Parlodel, reception of a preparation may be continued only under strict indications. At cancelling of Parlodel on early terms of pregnancy, its negative influence on current and an outcome of pregnancy is not noted. At approach of pregnancy at patients with an adenoma of a hypophysis treatment by Parlodel should be cancelled, establishing careful supervision over the patient during pregnancy. At occurrence of attributes of the expressed increase of a prolactinoma (for example occurrence of a headache or narrowing of fields of vision) treatment with Parlodel is possible to be renewed or operative intervention should be undertaken. Application of Parlodel at treatment of female barreness with the subsequent approach of pregnancy (over 2000 cases) was not accompanied by the raised risk of abortions, premature birth or developmental anomalies.

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Our community is dedicated to offering a friendly environment in which to chat about all things family related. Whether you are planning for your first or expecting another baby, you will always find like minded members to talk and make friends with. Look though our numerous subject specific forums or feel free post about anything you want to chat about. Join the community by Registering and don't forget to Introduce Yourself so we can all get to know you.

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I've just realized that I've been talking about going public and asking for help so we can hopefully afford IVF, yet most of you out there, dont have a clue what it's all about. I'm about to copy the description from the Victoria Fertility Centre website:


In Vitro Fertilization (IVF)

In-Vitro Fertilization, or IVF, is a process designed to help women
achieve pregnancy. There may be many reasons why a couple are unable to become pregnant, and a thorough investigation of both partners is appropriate before making any decisions about treatment.

The first baby born through IVF was Louise Brown, through the pioneering efforts of Drs Steptoe and Edwards, in 1978. Originally, IVF was designed to help women with tubal disease, but today IVF is able to help couples with many different problems achieve a healthy pregnancy.

Before explaining IVF it is important to have a basic understanding of the female menstrual cycle.

The Normal Menstrual Cycle
Women are born with a finite number of eggs. The ovaries are not like the testes in men. The testes are like sperm factories that continue to make fresh sperm all the time. The ovaries are more like of eggs. The ovaries are not autonomous (self-regulating), and need to be stimulated to function.

The ovaries are controlled by a hormone called FSH (follicle stimulating hormone) produced in the brain. At the start of each menstrual cycle the brain releases FSH and, in response, a number of eggs are or withdrawn from the . These eggs start maturing and each egg grows in a capsule of fluid called a follicle. A follicle is, in fact, a small cyst. Although many many eggs start on this journey, within a couple of days most will die and disappear, and only one or two will continue to grow and mature.

As the follicles grow they release a hormone called estradiol (estrogen). When the egg is almost mature, the rising estrogen level signals the brain to release a hormone called luteinizing hormone (LH). This hormone triggers ovulation, and it can be detected in a womans urine the day before she will ovulate. LH is the hormone that is detected by ovulation predictor kits.

Around the time of ovulation, the rising estrogen levels act on the mucus at the cervix, making it stringy like the white of an egg. Normally the cervical mucus is thick, and is designed to prevent any bacteria from getting in to the uterus from the vagina. The estrogen makes the mucus sperm-friendly so that the sperm are able to penetrate through the mucus and get into the uterus and then on to the fallopian tubes.

After ovulation the egg is picked up by the many tiny finger-like structures at the end of the fallopian tube called fimbria. A sperm will then fertilize the egg in the upper part of the tube. A fertilized egg is called a zygote and then, once it starts to divide, an embryo. The early embryo spends 35 days in the tube before it reaching the uterus where it will then implant in the uterine lining (the endometrium) and begins to grow.


What Happens in an IVF Cycle

During IVF you are given medications which manipulate your ovaries and the eggs being produced. The idea is to try and get several eggs to mature, not just one or two. The follicles where the eggs are developing can be monitored by ultrasound and by measuring your estrogen levels.
ULTRASOUND IMAGE OF OVARY CONTAINING FOLLICLES

When the eggs are mature, they are taken from the ovaries (using a fine needle which is passed through the vagina under ultrasound guidance) and handed to the embryologist. The eggs are then fertilized with your partner's sperm (or, in some instances, donor sperm).

The fertilized eggs (embryos) are then cultured under very strict conditions and examined each day by the embryologist to assess their progress. On the third day the embryos are assessed by the embryologist and a meeting is then held to discuss them. At this meeting we decide how many to replace inside the uterus (by a second procedure called an embryo transfer).

Sometimes more than one embryo will be transferred, and sometimes the other good quality embryos will be suitable for freezing for your later use. Our aim is to enhance the chances of pregnancy but limit the risk of multiple pregnancies.
Multiple Pregnancies

Although most couples are happy to accept a risk of twins, it is important to know that even twins carry significant risks (e.g. premature delivery, developmental abnormalities, toxaemia, gestational diabetes, etc, etc). So although in most cases the outcome with twins is good there are significantly increased risks of problems over .

Higher order multiple pregnancies such as triplets and quads carry extremely high risks and we do everything we can to avoid these. If a pregnancy does occur with triplets or more we would encourage you to consider a selective reduction. This is a procedure done at 1011 weeks gestation, whereby the number of fetuses is reduced to twins. It is like an amniocentesis, and does carry a risk about 5 % that the whole pregnancy could be miscarried. Ideally we try and avoid this scenario, which is upsetting to everyone.

Preparation for an IVF Cycle
In order to optimize results we recommend that you pay particular attention to both your physical and mental health both before and during the treatment phases. Both men and women are advised to stop smoking and drinking alcohol prior to treatment. We also recommend that women stop all caffeine as soon as they start medication and stay off it until the first pregnancy test. If pregnancy occurs we recommend no caffeine until 12 weeks gestation.

Optimal weight is very important, and being underweight or overweight can adversely influence the success of a cycle. The ideal body mass index (BMI) is between 20 and 25, and a BMI over 30 will both significantly reduce the chances of conception and increase the chance of miscarriage.

It is recommended that all women considering pregnancy take a prenatal supplement containing folic acid for at least a month or more before pregnancy, and then throughout the pregnancy. Materna is a popular prenatal vitamin. Folic acid has been shown to reduce the incidence of spina bifida and the ideal amount of folic that should be taken daily is 1 mg. Women in certain high-risk groups may need a higher dose to achieve the same protection. These include:

Women who are overweight
Diabetics
Women who have had a child with spinal bifida, or who have a relative with spinal bifida
Certain racial groups including Sikhs and women from some European countries such as Wales
Women who take anti-epileptic drugs

These groups of women are recommended to take 4 mg of folic acid daily.
You might be taking prescription drugs. Please make sure that you have discussed these with VFC before starting IVF treatment.
It is important to keep physically fit, although we would recommend that you moderate your exercise before an IVF cycle.
The Treatment Cycle - What to Expect
Although what follows is a "typical" approach every treatment is individualized and this is therefore just an example.

Step 1
History, physical examination, blood tests, sperm functional assessment, pelvic ultrasound
Possibly hysteroscopy/laparoscopy
Consultation with our reproductive psychologist
Setting an individually-designed treatment plan
Clinical orientation at VFC (with one of our Clinical Co-coordinators) to explain your treatment plan and make sure that you understand how to give injections and take medications

Step 2
You maybe asked to take the birth control pill (the ) for approximately 3 weeks. This suppresses the ovaries and the uterine lining (puts them to sleep). It also suppresses other hormones which in certain circumstances has a positive effect on outcome
While on the Pill you will be asked to come to VFC for a Mock Embryo Transfer. You will be given an instruction sheet about this process. The reason for the Mock Embryo Transfer is to check that there will not be any problems transferring the very delicate embryos into your uterus.

Step 3
After being on the Pill for 2 weeks, you will be started on a drug called a GnRH analogue. The commonly-used ones, Suprefact and Lupron, are given by injection once a day, preferably in the morning. This drug suppresses the pituitary gland in the brain, which prevents it releasing FSH and LH. This means that we can take complete control of the ovaries and uterus without any interference from the brain
After being on the GnRH analogue for 710 days, you will be asked to stop the Pill but you will continue to take the GnRH analogue. After stopping the Pill you will have a bleed (this is the lining of the uterus shedding).
You will then have an ultrasound to check that the ovaries are , i.e. that there are no follicular cysts on them. You will also have a blood test to check your estradiol level
If everything looks good you will be ready to start the stimulation phase of your cycle

Step 4: Stimulation Phase (ovulation induction)
You will continue with your GnRH analogue, aspirin and prenatal supplement
You will be started on injections of gonadotrophins, FSH and LH, to stimulate your ovaries. The names of the commonly used drugs are: Gonal F, Puregon and Repronex (although there are others). During your orientation session you will have been taught how to mix and inject these hormones
After approximately 7 days of stimulation you will have an estradiol (blood test) and ultrasound. The dosage of your gonadotrophin drugs might be adjusted at this stage

Step 5: The Follicles Are Ready
When the follicles reach a certain size and your estradiol levels are right you will be ready for . At this stage you will be asked to stop the GnRH analogue and FSH/LH (gonadotrophin) injections. You will be told then when to have an injection of another drug called hCG (trade names are Profasi or Pregnyl). The hCG the eggs and makes them ready for retrieval
You will also be asked to start taking an antibiotic called Doxycyline. You will take this twice a day until the day of your embryo transfer taking the last dose of Doxycycline that evening.
Your egg retrieval will be scheduled for exactly 36 hours after this injection

Step 6: Egg Retrieval
You will be asked to do the following the day before your egg retrieval:

1.Have a normal supper the night before retrieval, but nothing to eat after midnight

2.Continue to take the antibiotics as directed.

3.On arrival, you will be asked to empty your bladder and change into a nightgown

4.You will then be given acupuncture for half an hour. This helps you relax, and also helps control the discomfort during the egg retrieval

5.After the acupuncture you will be introduced to the RN (Registered Nurse) who will assist with your procedure. The RN will take you through to the Procedure Room, an intravenous line will be started, and you will be hooked up to an ECG and Oxygen Saturation Monitor

6.Your legs will then be positioned in stirrups just like when you have a Pap smear

7.A speculum will be introduced in to the vagina so that it can be cleaned thoroughly with sterile saline. Local anesthetic is then injected in to the vagina wall

8.During this time you will be given some medications called Fentanyl and Midazolam to control discomfort. These drugs will make you feel drowsy and relaxed. You will also be given an intravenous antibiotic to reduce the risk of infection

9.A vaginal ultrasound probe is then inserted into the vagina. A needle is passed alongside the probe, through the vagina wall into the ovaries, and the follicles are aspirated and their fluid collected in test tubes. The fluid is immediately examined by our embryologist. The eggs are identified, placed in culture medium and stored in an incubator. This whole procedure takes about 15 minutes

10.At the end of the procedure the probe is removed and you will rest until you are ready to go through to the Recovery Room. There you will rest until you feel ready to go home. During this time you will be offered a drink and some cookies

11.You will need to be escorted home by your partner or a friend. You must not drive for 24 hours after egg retrieval
12.After your egg retrieval, unless you are using frozen/donor sperm, your partner will be asked to produce a fresh semen sample at VFC

13.The sperm are then washed and prepared in the laboratory by our embryologist

14.The eggs are then inseminated either by mixing the sperm and eggs together (standard IVF) or by ICSI (ICSI stands for Intracytoplasmic sperm injection and involves injecting a single sperm into each egg). ICSI is performed only if we have concerns about the sperm and their ability to fertilize an egg. In either case, fertilization actually occurs several hours later

15.After egg retrieval you will be asked to start your progesterone to prepare the uterine lining for the embryo transfer which will take place on the third day after the egg retrieval. Progesterone is usually given in one of two ways:

a.Prometrium: This comes in 100mg tablets which are inserted in to the vagina. The usual dose is 200 mg (2 tablets) 3 times daily
b. Progesterone in oil: This is given by intra-muscular () injection, the usual dose is 50 mg per day. These injections might need to be given at VFC or by your family doctor daily

Step 7: The Short Wait....
This is the 3-day period between egg retrieval and embryo transfer.
The day after egg retrieval you will be telephoned to tell you how many eggs have fertilized. The fertilized eggs (zygotes) are cultured under carefully controlled conditions for 3 days. Zygotes should divide into 2 cells later on the first day and are then called embryos. On the morning of the second day the embryos should have 4 cells each, and 8 cells by the morning of the third day
During these three days you may do everyday activities but you will be asked to refrain from
Intercourse
Swimming or hot tubs
Coffee and alcohol
You should continue with your prenatal vitamins. You should continue with the progesterone preparation until told otherwise

Step 8: Day 3 The Embryo Transfer
On the day of embryo transfer you will be asked to come to VFC at the specified time
You should drink 2 glasses of water an hour before your transfer ideally we would like your bladder to be half full but not uncomfortable
We will discuss the embryos, their quality and confirm how many to transfer and freeze
You will be shown to the Procedure Room, and given acupuncture for 30 minutes
An ultrasound will then be done to check how full your bladder is
When ready, your legs will again be placed in some stirrups, a speculum introduced into the vagina and the cervix cleaned with saline
With an ultrasound probe on your tummy a fine catheter will then be passed through your cervix and the embryo(s) injected in to the uterus
You will then be asked to lie quietly for at least 20 to 30 minutes
After this you will be allowed to go home. You should rest quietly for the rest of the day but dont worry, the embryos wont fall out

Step 9: The Long Wait....
This is the 12-day wait between your embryo transfer and the expected date of your next period (which hopefully wont come for many months!).
You will be instructed to continue with the progesterone and prenatal vitamins and any other medications that might be necessary
You will be given a requisition to have a pregnancy test on a specified date.
During this time we would encourage you to:
Avoid intercourse
Restrict exercise to everyday activities only
Get lots of rest
Think positively!!!

Expectations

It is important to be well-informed and have realistic expectations. Some important points are:
Not every follicle contains an egg. So, if for example 10 follicles were identified by ultrasound prior to retrieval, it would be realistic to hope for 5 7 eggs
The number and quality of eggs can also be predicted to some extent by the levels of estradiol
Not every egg is good quality so not every egg fertilizes. We expect a fertilization rate of about 80%
Not every fertilized egg develops into a perfect embryo
On Day 3 our embryologist assesses the embryos according to very strict criteria to help us decide which embryos to choose for transfer
Not every embryo that is not transferred is suitable for freezing. Poorer quality embryos are unlikely to survive freezing and thawing and may be discarded
The table below gives some idea of IVF/ICSI cycles for average patients

Schematic Summary of an IVF Cycle
Birth control pill for 2 weeks

Add Suprefact and continue the Pill for 1 week

Stop the Pill continue Suprefact
Expect vaginal bleed continue Suprefact only

Ultrasound and estradiol (blood test)
If satisfactory, start HMG (Gonal F, Puregon, Repronex)

After 7 days of HMG, repeat ultrasound and estradiol
Further monitoring until follicles are
Trigger with hCG (Profasi or Pregnyl)

Egg retrieval Fertilization Embryo culture

Embryo transfer

Pregnancy test
Risks and Possible Complications Related to Superovulation and IVF/ICSI
1.) Canceled Cycles

A cycle might be canceled for a variety of reasons, the most common of which are either an under- or over-response to the fertility drugs. We do our best to predict the ovaries likely responses to the fertility drugs, and choose a dosage that is most appropriate to your individual characteristics. The ovaries are assessed pre-IVF by doing a Day 3 FSH level, and by examining them using ultrasound. Your weight and age are also important considerations.

Older women, elevated FSH levels, and previous poor response to stimulation are all factors that may predict a poor response to these medications. In these situations, a protocol will be selected to try and get the most from your ovaries. However, sometimes there is such a poor response that the cycle has to be abandoned.

On the other hand, sometimes the ovaries over-respond. Women at risk for this are those with polycystic ovarian syndrome (PCOS), and women who are overweight and not menstruating regularly.

One of the potential complications from over-responding is a condition called ovarian hyper-stimulation syndrome (OHSS). This is a potentially dangerous condition that results from the estrogen levels being too high. This causes the membranes between fluid compartments in your body to become too permeable, resulting in fluid leaking into body cavities such as the peritoneal cavity (abdomen) and the pleural spaces (chest, around the lungs). OHSS also tends to result in the fluid volume in your blood vessels (the intravascular volume) falling, leading to a hypercoagulable state in other words, you may be more prone to blood clots and stroke.

There are several ways to identify this condition (OHSS), and precautions that can be taken to prevent serious complications. If, during the stimulation phase of the cycle, too many follicles start growing, and the estrogen levels get too high, different options become available. This situation usually only becomes dangerous if the hCG is given, or if pregnancy occurs. The different options include:
Coasting stopping the FSH drugs and waiting for the estrogen levels to come down before giving hCG.
Retrieving and fertilizing the eggs, but then freezing all the embryos for later use; so that pregnancy will not occur until the ovaries and estrogen levels have had a chance to settle down.
Canceling the cycle completely.

Common symptoms associated with OHSS include bloating, nausea, abdominal pain, shortness of breath, vomiting and low urine output. Many cases are mild and respond to simple measures such as fluid manipulations.
2.) Surgical Complications from the Egg Retrieval

Potential complications from this procedure include the following:
Internal bleeding
Infection
Damage to internal organs such as the bladder, bowel or ureters
These are all very uncommon.

3.) Ovarian Complications

After IVF the ovaries become swollen and tender. They can be very uncomfortable and can occasionally twist or bleed. Very rarely it might be necessary to do a surgical procedure to untwist them or stop them bleeding.

4.) Multiple Pregnancy

It is our duty to do the very best to achieve pregnancy while also reducing the risk of multiple pregnancy. Even twins carry significant risks, some of which are listed below:
Increased social or domestic stress with child raising.
Increased chance of premature delivery, with all the associated risks such as cerebral palsy, learning disorders, low birth weight, congenital anomalies, etc.
Increased pregnancy risks, such as toxaemia (high blood pressure), gestational diabetes, anaemia, operative delivery, miscarriage, post-partum bleeding, etc.
Some of the ways to reduce the risks of a multiple pregnancy include:
Limiting the number of embryos transferred
Transferring only one embryo
Selective reduction

5.) Long-term Risks of Cancer

There have been concerns raised over the years that there might be long-term cancer risks associated with the use of fertility drugs.

One study in Washington State revealed that an unusual number of women with cancer had used a fertility drug called Clomiphene. However, subsequent studies that have been done are more, reassuring. There are many other factors that might be associated with an increased risk of ovarian cancer, one of which is infertility itself.

Recently, some studies have suggested a possible increase in the risk of breast cancer associated with the use of FSH (e.g. Gonal F, Puregon, Repronex), although once again the findings across all relevant studies are inconclusive.

At this present time the Cochrane review does not support an association between IVF, Fertility drugs and breast or ovarian cancer.
The bottom line is that there may be a risk, and these drugs should be used responsibly, on each occasion maximizing the chance of a pregnancy so as to reduce long-term (repeated) exposure.

6.) Risks of IVF and ICSI to Children

So far, the studies done looking at children born after IVF and ICSI have been very reassuring. There is some evidence that children born after IVF/ICSI might have a slightly lower birth weight than children conceived naturally.

Recent evidence suggests that there might be a slightly higher risk of congenital abnormalities in children born after ICSI, but not IVF. It should be remembered that all babies born (i.e.naturally conceived babies) have a 46% risk of some form of congenital abnormality. These should not be confused with the genetic problems that increase with maternal age. Common congenital abnormalities include such things as club foot, cleft palate, extra digits, hernias, etc, which are not related to maternal age. However, it must also be remembered that babies born after IVF and ICSI are far more carefully scrutinized than babies conceived naturally.

Nonetheless, it is important that you are aware that there is a likelihood that a male sperm problem, if it is something you were born with, will probably be transmitted to your sons via the Y chromosome.

Having said all this, for the most part, the information available is reassuring.

7.) Miscarriage

Miscarriage can occur in up to 1020% of pregnancies, depending on maternal age. The rate of miscarriage may be higher with IVF/ICSI than in natural conception cycles, although this could be influenced by personal history and health. There may also be an increased risk of ectopic pregnancy, especially if there is a history of damaged fallopian tubes.
Dealing With Bad News A Failed Cycle or Obtaining Fewer Than Expected Eggs or Embryos
Unfortunately, one has to be realistic about IVF success rates. It is recommended that dealing with a failed cycle be discussed beforehand, and that plans are made for receiving the pregnancy test result on the appointed day. A failed cycle often leave women with feelings of frustration, sadness and even despair. This is why we encourage all our patients at VFC to meet with our reproductive psychologist at the start of a treatment cycle.



Alright, how do you like that? Not quite what you thought it was going to be, was it? The thought of actually going through that, scares the shit out of me, but I'm willing to do it. The need to have a baby is so intense and so ingrained in us we're willing to do whatever it takes for it to finally happen. To finally have what everyone else gets, so easily.

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The hypothalmus, a region in the brain, first releases a hormone called gonadotropin releasing hormone GnRH. O Excessive facial hair o Thinning hair o Acne o Depression o Diuretics weight gain o Irregular or no periods o High insulin or cholesterol readings. Often the cause is excessive exercise or anorexia.
Vitamins and Minerals for a Healthy Reproductive S. Causes of ovarian cysts forming in the endometrial tissue include bleeding and sloughing off of endometrial tissue that transplants itself in the ovaries. S not even clear when John McCain will arrive. Jeff Buckley, Tim Buckley, Freddie Mercury, Paul Kossoff, John Bonham, Stuart Adamson amp. On Thursday, October th, at am and is filed under.

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Rarely, a hormonal difficulty that decreases or stops the mans production of sperm. Urine tests to evaluate LH surges. Caliber Glock Model semi automatic pistol.
Other easily treated illnesses or lifestyle habits that may contribute to infertility are. Soma solution for body builders online. Org and look under mental health. What happened to the shooter I felt his whole. Clomiphene This drug triggers the release of FSH and LH, boosting egg growth and helping the ovaries release a monthly egg. Women who have trouble ovulating, endometriosis, infertility caused by cervical problems or allergen infertility are good candidates for this drug.

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Incidence of Adverse Events in Clinical Studies Events Greater than n. Ovulation most often occurs from to days after a course of CLOMID.
I will second Merlins request for your spiking procedure. Tablets are round, white, scored, and debossed CLOMID. Dosages of the composition may be administered in a Mtx aal 1540 formulation that would give rise to peak serum testosterone levels between about a. In some instances, the spiking should be done with a solution of your analyte rather than directly spiking the material in powder form. Institution Google Indexer Sign In as Personal Subscriber amp.

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Unlike in some countries, Ajerican political parties ade verh po osely organized. The fw major parties, in partisular, hxve no formsl organization zy the national level t hat controls membrship, activities, or polkkcy positions, though somme state affiliates d. Thus, for an American to say that he or she is a member of teu Democratic or Republican part y, is quie different from a Britons stating that hw or she iz a member of the Labour party.

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There can be premature birth danger because of falling level of progesterone or low progesterone. The differentiation that appear in the breast is as a result of progesterone and it stimulates breast milk. The foetus is determined by the amount of progesterone. The correct levels will act as a stabiliser of the pregnancy whereas, low progesterone levels can stop pregnancy happening or influence miscarriage or other problems occurring while pregnant. It has been documented that infertility problem is a result of low level of progesterone.
How can the Problem low level of progesterone be Addressed?
If you are having difficulty conceiving or in the past have miscarriaged, you should seek the opinion of the medical expert to access the level of progesterone and other hormone. The most popular causes of infertility has been discover to be low progesterone. Other contributing factors has been associated to modern scientific ways of living. For instance, modern farming techniques whereby chickens, cattles and other livestock were and still been injected with hormones for rapid growth.
There are some evidence that suggest, eating poultry, and meat which has been injected with hormones do cause adverse effect. Definitely, there will be further studies like before to uncover the truth because it appear that low progesterone infertility and human fertility are symptoms. You should also note that aluminium foil packaging and artificial sweeteners are said to be other contributing factors having negative effect on our lives and also increases the occurrence of infertility in men and women.

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